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Abstract Details

Upper Extremity Motor Symptoms’ Severity Estimation with Ecologically Valid Data Arising from Smartphone Touchscreen
Movement Disorders
P10 - Poster Session 10 (5:30 PM-6:30 PM)
3-011
The study aims to provide an objective passive monitoring tool for the fine-motor impairment as reflected by the clinical evaluation of UPDRS Part III Single item scores, by analyzing touchscreen typing data of healthy and early Parkinson's Disease patients. 

Objective high frequency data arising from everyday devices can be used to monitor habits of individuals that can be linked to health status, and further used for monitoring and early detection of motor impairment. Exploiting the sensing capabilities of smartphones, these data could be deployed to perform large-scale human studies. Aiming towards early detection of Parkinson's Disease, touchscreen data were collected passively from two clinically examined cohorts via a mobile app (iPrognosis) and were analyzed in order to find the ability of app-derived indices capturing the severity of bradykinesia and rigidity. 
The study was designed hereby by employing a cohort of 33 (demographically-matched 18/15 PD/healthy controls) that typed multiple text excerpts in-the-clinic. By analyzing the timing sequences (press and release actions) of the keystroke typing activity and employing machine learning, two indices were created: RSi and BSi for Rigidity and Bradykinesia Severity index, respectively. A separate cohort, comprising of 15/8 PD/Healthy controls, used the iPrognosis keyboard as the default input method for their routine typing activities on their smartphones. In order to aggregate the produced indices in a subject-level, median of the total produced indices was calculated and was compared to the clinical labels. 
Correlation of the predicted indices with the UPDRS Part III single item scores achieved 0.71, 0.64 and 0.54 with the alternate finger tapping test, bradykinesia and rigidity of the subjects, respectively. Moreover, the diagnostic performance achieved was 0.9 area under the receiver operating characteristics curve.
Touchscreen based indices hereby show promising performance on detecting the severity of fine-motor impairment even when data is captured in-the-wild.
Authors/Disclosures
Sevasti Bostantjopoulou-Kambouroglou, MD
PRESENTER 		No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
IOANNIS DAGKLIS No disclosure on file
Sevasti Bostantjopoulou-Kambouroglou, MD No disclosure on file
Zoe Katsarou, MD No disclosure on file
Dhaval Trivedi No disclosure on file
No disclosure on file
No disclosure on file
Heinz Reichmann, MD, FÂ鶹´«Ã½Ó³»­ (Dept. Neurology) Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bial. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Zambon. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Kyowa. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Bial. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Zambon. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Kyowa. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bial. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Zambon. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for UCB. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Thieme. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wissenschaftsverlag.
No disclosure on file