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Abstract Details

Hyponatremia as an independent predictor of mortality and functional outcome in stroke
Cerebrovascular Disease and Interventional Neurology
P10 - Poster Session 10 (5:30 PM-6:30 PM)
4-007
To observe the effect of hyponatremia on mortality and functional outcome in hospitalized stroke patients.
Hyponatremia is the most common electrolyte imbalance in stroke and may negatively affect the mortality and functional outcome in stroke.
This prospective analytical cohort study, carried out in Department of Neurology of National Institute of Neurosciences & Hospital, Dhaka from July 2017 to December 2017 included 229 patients admitted with acute stroke (65 ischemic, 164 hemorrhagic). Patient characteristics, in-hospital measures, mortality and functional outcome by modified Rankin Scale (at discharge and at 30 and 90 days) were analyzed to determine the effects of hyponatremia (Na<135 mmol/L). Multivariable regression analyses were calculated for predictors of mortality at 90 days.
Of 229 patients 65 (28.4%) were hospitalized for acute ischemic stroke, 144 (62.9%) for acute intracerebral hemorrhage (ICH) and 20 (8.7%) for acute subarachnoid hemorrhage (SAH). Five died before the serum could be sent for electrolytes (3 ICH, 1 SAH and 1 ischemic). Of the rest, hyponatremia was detected in 39 (17.4%). There was no significant difference of frequency of hyponatremia among different types of stroke (Ischemic vs. ICH vs. SAH: 17.2% vs. 17.7% vs. 15.8%; p=0.977). Syndrome of inappropriate Diuresis (SIAD) was the most frequent cause of hyponatremia (51.3%), followed by cerebral salt wasting (CSW; 30.8%). Although hyponatremia in both types of stroke was associated with higher mortality and poorer functional outcome at discharge, 30 day and 90 day, this was not statistically significant.
Nearly 1 in 5 patients with acute stroke have hyponatremia. Although a trend of higher mortality and poorer functional outcome is observed in stroke patients with hyponatremia, it is not statistically significant.
Authors/Disclosures
Maliha Hakim, MD (National Institute of Neurosciences Hospital)
PRESENTER 		No disclosure on file
No disclosure on file