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Abstract Details

Irregular Diurnal Rhythmicity and Cerebrovascular Pathology in Older Adults
Aging, Dementia, and Behavioral Neurology
P10 - Poster Session 10 (5:30 PM-6:30 PM)
10-010
 To investigate the associations between cerebrovascular pathology and diurnal rhythmicity in older adults.
Circadian rhythmicity is important for many aspects of human health, and other studies have shown that irregular diurnal rest-activity rhythms are associated with the metabolic syndrome and its component vascular risk factors, and with clinical cardiovascular and cerebrovascular outcomes. However, few studies have assessed the association between diurnal rest-activity rhythms and cerebrovascular pathology in the human brain. We tested the hypothesis that greater interdaily stability (IS), a measure of the regularity of diurnal rhythmicity derived from actigraphy, is associated with a lower burden of cerebrovascular pathology in community dwelling older adults.
We studied 539 deceased participants from the Rush Memory and Aging Project, a community-based cohort study of older adults. The regularity of diurnal rest-activity rhythms was quantified from up to 10 days of actigraphy using the interdaily stability (IS) metric.  The burden of arteriolosclerosis, atherosclerosis, and macroscopic and microscopic infarcts was quantified by structured autopsy.  We used ordinal logistic regression models to assess the relationship between IS and the burden of cerebrovascular pathology.
Greater interdaily stability was associated with less severe arteriolosclerosis (OR= 0.82, 95% CI = 0.70-0.96, p = 0.015) and with a lower number of gross subcortical infarcts (OR= 0.82, 95% CI = 0.68-0.99, p = 0.035).  In models adjusted for vascular risk factors, these associations remain unchanged.
In older community-dwelling adults, more regular diurnal rest-activity rhythms are associated with a lower burden of arteriolosclerosis and subcortical infarcts.
Authors/Disclosures
Rosa Sommer
PRESENTER 		No disclosure on file
No disclosure on file
Julie A. Schneider, MD, MS (Rush Alzheimer'S Disease Center) Dr. Schneider has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Dr. Schneider has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for alnylam. Dr. Schneider has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for apellis. Dr. Schneider has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for National Hockey League. The institution of Dr. Schneider has received research support from NIH. Dr. Schneider has received personal compensation in the range of $500-$4,999 for serving as a scientific advisor with Fondation Alzheimer, France.
David A. Bennett, MD (Rush University Medical Center) Dr. Bennett has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Annovis. Dr. Bennett has received personal compensation in the range of $500-$4,999 for serving as a Consultant for New Amsterdam. Dr. Bennett has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AbbVie. Dr. Bennett has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AbbVie.
Aron S. Buchman, MD (Rush Alzheimer's Disease Center) No disclosure on file
Andrew Lim, MD (Univ Toronto / Lim and Hew Med Prof Corp) Dr. Lim has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai Canada.