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Abstract Details

Electrocardiographic Changes in Status Epilepticus in African American Patients
Epilepsy
P03 - (-)
128
BACKGROUND: Among the multiple causes of high mortality and morbidity associated with status epilepticus, evidence suggests that changes in cardiac function can play a crucial role in patients with worse outcomes.
DESIGN/METHODS: Retrospective analysis of the types of EKG changes with comparison of EKGs taken within 6 hours and after 24 hours in patients with Status. 113 African American patients with Status were included, age > 15 years, admitted to Howard University Hospital with Status Epilepticus between January 2007- December 2011. HUH Cardiology interpreted EKGs for parameters of rate, QRS axis, PR and QT interval, ST changes and voltage as well as types of rhythm and abnormalities.
RESULTS: Demonstrates that 81% (92) of patients showed abnormal EKG pattern in < 6 hours from the onset of SE, most commonly ischemic changes 39%, (N =36) conduction defects 30% (N= 28) and arrhythmia 21% (N= 19). This suggests that significant risk factors of cardiac stress occur with SE. Most EKG abnormalities resolved spontaneously, however potentially life threatening EKG abnormalities that did not resolve within a reasonable time were treated. Mortality and morbidity were higher in Status associated with new onset seizures. The overall mortality was 9% (N=8) Patients with EKG abnormalities during SE (81% N= 92) had significant higher mortality than those without EKG Changes (19% N=26). 88% (N=7) of the patients who died developed EKG abnormalities which persist.
CONCLUSIONS: Based on the study result we recommend that all patients presenting with SE particularly new onset seizures and those with GTC status should have serial monitoring of EKGs for persistent abnormalities, as part of evaluation and treatment plan to allow early detection of potentially life threatening cardiovascular risk.
Authors/Disclosures
Noha O. Solieman, MD (Tawam Hospital)
PRESENTER 		No disclosure on file
No disclosure on file
Mohankumar Kurukumbi, MD Dr. Kurukumbi has nothing to disclose.
Annapurni J. Trouth, MD, FÂ鶹´«Ã½Ó³»­ (Howard Univ Hosp - Neurology Retired) No disclosure on file
No disclosure on file